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While these PK and PD data may support administration of apixaban without dose adjustment in patients with mild or moderate hepatic impairment, these results should be interpreted with caution, especially in the presence of more severe hepatic impairment or other risk factors for bleeding

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Gastrointestinal adverse events were mostly mild, transient, and occurred during dose escalation, with only one participant discontinuing treatment due to gastrointestinal symptoms after the third dose

No, as of now there are no large-scale human clinical trials specifically for herniated discs